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KMID : 0616120160470040295
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Korean Journal of Pharmacognosy
2016 Volume.47 No. 4 p.295 ~ p.300
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Inhibitory Effects of Kaempferol-7-O-β-D-glucoside on LPS-induced NO, PGE2 and Inflammatory Cytokines Production in RAW264.7 Macrophages
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Park Jong-Cheol
Han Hee-Soo
Lee Seung-Bin
Lee Kyung-Tae
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Abstract
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Flavonoids are widely reported to be beneficial to human health. Among flavonoids, in general, flavonoid aglycons have better biological activities than flavonoid glycosides, in that aglycons can easily penetrate through cell membrane because of their low polarity. Therefore, kaempferol, quercetin and various their glycosides were evaluated for their abilities to inhibit NO and PGE2 productions in LPS-induced RAW 264.7 cells. Of these flavonoids and flavonoid glycosides, kaempferol-7-O-β-D-glucoside(kp-7-glu) which possesses a glycoside at C-7 position of the A ring in kaempferol, potently inhibited NO, PGE2 and TNF-α, IL-1β, IL-6 productions in LPS-induced RAW 264.7 macrophages.
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KEYWORD
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Flavonoids, Kaempferol-7-O-β-D-glucoside, NO, PGE2, RAW 264.7 macrophage
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